全麻时监测临床病人神经活动状态的新方法

A New Method for Monitoring the Status of Central Nervous System during General Anesthesia

目的探讨全麻时神经活动的状态,寻找对全麻时神经活动状态进行检测的新方法。方法随机采集了临床外科全麻胸腹手术中18位病人的双通道(FP1-Cz,FP2-Cz)脑电数据,通过分析EEG的Kol-mogorov熵的变化趋势,进而判断全麻时病人神经活动的状态。结果同一种麻醉措施作用下,大部分病人神经活动的状态是相同的,但也存在个体差异:同一种麻醉措施,有些病人大脑皮层前额叶区域的中枢神经系统呈现抑制状态,有些则呈现兴奋状态,还有些呈现癫痫状态。结论同一种麻醉药品对不同被试者其作用会有差别;通过分析全麻状态下脑电信号Kolmogorov熵的变化能够有效检测中枢神经活动的状态;Kolmogorov熵能成为临床麻醉监测的一种新工具。

Objective To investigate the status of central nervous system （CNS） during general anesthesia using a new method of monitor. Methods Eighteen patients during general anesthesia were randomly chosen as the subjects. EEG signals of the patients were recorded as the subject was undergoing a surgical operation. Status of CNS of the patients during general anesthesia was monitored through the changes of Kolmogorov entropy （KE） of the EEG signals. Results Under the same kind of anesthesia measures, though most patients＇ CNS presented roughly the same status, but important differences were found in individual cases. Some presented depressed CNS status, some presented excited CNS status and others presented epileptic status. Conclusion The same general anesthesia may have different effects on different subjects. KE can reflect the status of the prefrontal cortex during general anesthesia. KE may be a new tool for monitoring the status of CNS during general anesthesia.