6505例孕中期妇女开放性神经管缺损产前筛查结果分析

Analysis of prenatal monitoring for open neural tube defects in 6 505 pregnant women at mid-gestation period

目的分析多胎妊娠、吸烟、年龄对甲胎蛋白（AFP）监测结果的影响，比较不同年龄孕妇参加产前监测的时间差异。方法对6505例孕中期妇女开放性神经管缺损产前筛查结果进行回顾性分析，比较多胎妊娠与单胎妊娠、吸烟与否和不同年龄组孕妇AFP异常率和不同年龄孕妇参加产前监测的时间差异。结果吸烟和孕妇年龄对AFP监测结果没有明显影响，多胎妊娠AFP水平比单胎妊娠高1倍以上，不同年龄段的孕妇参加产前监测的时间存在不同程度差异。结论吸烟和孕妇年龄对开放性神经管缺损产前筛查结果不会产生明显影响；分析开放性神经管缺损产前筛查结果时必须考虑多胎妊娠的影响；不同年龄孕妇参加产前监测时间的差异可能与不同年龄孕妇对怀孕的认识和心理接受程度有关。

Objective To analyze the effects of multifetation, smoking and age on alpha fetoprotein （AFP） results in pregnant women, and to compare the time difference of prenatal monitoring for pregnant women in different age, Methods A retrospective study was carried out on open neural tube defects in 6 505 pregnant women at midgestation period. The effects of multifetation, smoking and age on AFP and time difference of prenatal monitoring for pregnant women in different age were analyzed and compared, Results Smoking and age had no obvious effects on AFP result in pregnant women, the AFP result of multifetation women was twice higher than that of monocyesis, and there was significant time difference of prenatal monitoring for pregnant women in different age. Conclusion Smoking and age have no obvious effects on prenatal monitoring for open neural tube defects. It＇s necessary to consider the effect of multifetation on prenatal monitoring results. The time difference of prenatal monitoring for pregnant women in different age may be related to their recognition and the extent of psychological receptivity.