整合素与肿瘤的靶向治疗

Integrins and Targeted Therapy of Cancer Therapy

整合素是细胞表面重要的黏附分子,介导细胞与细胞外基质相互作用,在肿瘤的发生发展过程中起着重要的作用,近年来将整合素作为肿瘤治疗靶点取得了显著的进展。目前采用针对整合素不同亚基的克隆抗体,整合素抑制剂,靶向节调整合素基因表达,整合素介导的溶细胞作用以及肿瘤细胞的整合素疫苗等方法通过调节整合素的生物学作用,促进肿瘤细胞凋亡,阻断肿瘤细胞侵袭迁移,抑制肿瘤血管的生成,从而达到治疗肿瘤的目的。这些研究发现对开拓肿瘤治疗新方案有着重要的意义。

Integrins is the important adhesion molecule on the cell surface, which can mediate interactions between cells and the extracelluar matrix and play an important role in the genesis and devel opment of tumor. Great progresses have been achieved about integrins as the targeted therapy of cance therapy. Now many methods regulating biological effects of integrins, such as methods aiming at clon, antibody of different subunit of integrins, inhibitor of integrins, targeted regulated expression of integrins gene,cytolysis mediated by integrins, integrins vaccine of tumor ceils, and so on, can cure tumor b, promoting tumor cell apoptosis,blocking the invasion and metastasis of tumor,inhibitlng angiogenesis of tumor.These studies have great significance for exploring new therapy for tumor.