摘要
细胞间的信息传递在细胞发育分化过程中扮演着重要角色。Notch信号通路作为一种进化上相对保守的细胞相互作用机制,维持着细胞增殖、分化、凋亡之间的平衡,其能够扩大并固化相邻细胞之间的分子差异,对细胞分化命运起决定性作用。本文综述了Notch蛋白的基本结构、Notch信号通路的激活方式、其主要相关分子以及Notch信号通路在肝癌中的作用。
The information transmission between cells play an critical role in cell differentiation and development.The Notch signal pathway is a conservative mechanism between cells,which keep the balance of cell proliferation,differentiation and apoptosis,and enlarge and rigidificate molecule difference between cells and determine the cell differentiation.This paper discussed the basic structure of Notch protein,activation modus and main components of Notch signal pathway and the function of Notch signal pathway in hepatoma.
出处
《医学综述》
2008年第1期65-67,共3页
Medical Recapitulate
基金
河北省自然科学基金(C2007001063)
