脚桥核与帕金森病关系的研究

Research about Relationship Between Pedunculopontine Nucleus and Parkinson's Disease

帕金森病是一种以中脑黑质多巴胺能神经元变性缺失为主要病理变化的渐进性神经系统退行性疾病。近年研究发现,帕金森病的难治性症状如运动不能、步态障碍和姿势异常与脚桥核有关,脚桥核作为基底节和脊髓的中介核团起着重要的运动调控作用。动物实验和临床研究显示低频电刺激脚桥核可明显改善帕金森运动不能症状。文章针对脚桥核的解剖、生理、神经纤维联系及其和帕金森病的关系简要综述。

Parkinson＇s disease （PD）, is a progressively neurodegenerative disorder, resulting from the degeneration and loss of dopaminergic neurons in the substantia nigra of midbraln. In recent years, a number of reports had showed that many refractory symptoms of PD such as akinesis, gait disorder and posture abnormality were related to pedunculopontine nucleus, which played a significant role in the movement regulation as the in-tercalatus nucleus to basal ganglia and spinal cord. Animal experiment and clinical study showed that low fre-quency electric stimulation on pedunculopontine nucleus （PPN） could obviously reduce the akinesis of PG. This article reviews PPN about its anatomy, physiology, nerve fiber contaction and its relationship with PD.