噻吩并[2，3-b]吡啶化合物的合成及应用

Advances in Synthesis and Applications of Thieno[2,3-b] pyridine Derivatives

噻吩并[2,3-b]吡啶化合物是一类重要的具有广泛生物活性的稠杂环,它们在杀菌、消炎、抗肿瘤和癌症等方面有很好的疗效,可以用作镇静剂及治疗高血压,哮喘病,糖尿病,溃疡病和神经性疾病的药物。除在农药,医药上的用途外,还可用作染料,缓蚀剂等。该类化合物在结构上类似于喹啉类稠杂环,其合成方法从反应物来区分,可分为以下3种情形:(1)以吡啶环为母环;(2)以噻吩环为母环;(3)不饱和硫酮化合物缩合。综述了该类化合物的合成进展及应用情况。

Thieno [ 2,3-b ] pyridine derivatives are of great importance because of their remarkable biological properties. They are of chemical and pharmacological interests due to their isosterism with quinolines and isoquinolines, two important heterocycles involved in many alkaloids. Some of them have been used as herbicides, fungicides, pesticides, medicines and dyes. Three general routes have been described so far for the preparation of thieno [ 2,3-b ] pyridine derivatives of this ring system ： a） formation of the thiophene ring by cyclization of suitable substitutents of a pyridine; b）formation of the pyridine ring by cyclization of a suitable thiophene; c）condensation of unsaturated thionone derivatives. This paper reviews the advances in synthesis and applications of thieno [ 2,3-b ] pyridine derivatives.