摘要
目的 建立紫外分光光度法测定塞曲司特片的溶出度。方法 于400～200nm波长处扫描，确定塞曲司特在266nm处有最大吸收。结果 塞曲司特浓度与吸光度值A呈良好的线性关系，线性范围4-20μg·mL^-1（r=0．9994），平均回收率为100．2％，RSD为0．45％（n=3）。结论 该方法测定塞曲司特片溶出度，结果准确，重现性好。
OBJECTIVE To establish an UV spectrophotography method for dissolution determination of Seratrodast tablets. METHODS To scan in the wavelength range of 400-200nm,and make sure Seratrodast had the largest absorption at wave length of 266nm. RESULTS The absorption was linear in the concentration range of 4-20μg·mL^-1 （ r =0. 9994）. The average recovery was 99. 9%, RSD = 0. 45% （ n = 3）. CONCLUSION The method was good,accurate and reproducible.
出处
《齐鲁药事》
2008年第1期25-26,共2页
qilu pharmaceutical affairs
关键词
塞曲司特片
溶出度
紫外分光光度法
Seratrodast Tablets
dissolution
UV spectrophotography
