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tSAH患者血清内皮素与神经元特异性烯醇化酶的动态检测 被引量：2

Clinical study of serum ET and NSE levels in patients with traumatic subarachnoid hemorrhage
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摘要 目的观察外伤性蛛网膜下腔出(tSAH)患者血清中内皮素-1(ET-1),神经元特异性烯醇化酶(NSE)水平的变化。方法用双抗体夹心酶标免疫分析法和放免法检测50例外伤性蛛网膜下腔出血患者发病24h内、第3、7、14d血清中ET、NSE的水平并与对照组比较。结果外伤性蛛网膜下腔出血患者血清中ET水平较正常对照组高(P<0.01),第3、7d升高明显,第14d有降低但仍高于对照组,血清中NSE水平第7d达高峰。结论ET、NSE的变化可以反映蛛网膜下腔出后脑损伤程度。 Objective To study the serum endothelin-1 （ET-1） and neuronspecific enolase （NSE）levels in patient with traumatic subarachnoid hemorrhage （tSAH）. Methods The serum ET-1 and NSE levels at 1, 3, 7 and 14 d after onset of tSAH in 50 patients were detected by radio-immunediffusion and double antibody sandwich enzynre-tinked immunosorbent assay. Results The serum ET-1 and NSE levels in patients with tSAH were higher than that of the normal control （P 〈 0. 01 ）. The highest levels of ET appeared at 3 d and 7 d and NSE level reached the peak at 7 d. Conclusion The levels of ET-1 and NSE may reflect the brain damage degree after tSAH.
作者 史建国 姜勇 董亚南 高军 孟雷 高松
机构地区 济南市中心医院神经外科
出处 《中华神经外科疾病研究杂志》 CAS 2008年第1期4-6,共3页 Chinese Journal of Neurosurgical Disease Research
关键词 蛛网膜下腔出血 内皮素-1 神经元特异性烯醇化酶 Subarachnoid hemorrhage Endothelin-1 Neuronspecific enolase
分类号 R743.35 [医药卫生—神经病学与精神病学]
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参考文献10

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二级参考文献28

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中华神经外科疾病研究杂志
2008年 第1期

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