高血压脑出血患者血清S-100蛋白的表达及手术对其影响

Expression of the serum S-100 protein concentration in hypertensive intracerebral hemorrhage patients and the effect of surgery

目的探讨高血压脑出血患者血清S-100蛋白的表达及手术治疗对其影响和临床意义。方法选择出血量30～50ml的高血压脑出血患者67例，分为手术组35例和保守组32例。用酶联免疫吸附测定法（ELISA）动态测定血清中S-100蛋白的含量。结果①保守组患者S-100蛋白浓度在发病21d内高于正常组（P〈0．01）；②手术组患者S-100蛋白浓度在发病7d内高于正常组（P〈0．01），15d和21d时与正常组比较无显著性差异（P〉0．05）；③手术组患者S-100蛋白浓度在发病3d内与保守组比较无显著性差异（P〉0．05），但下降较快，在7d时低于保守组，在15d和21d时明显低于保守组（P〈0．001）。结论手术清除血肿可以减轻高血压脑出血患者的脑损伤。

Objective To explore the effect of surgery on the serum S-100 protein concentration in hypertensive intracerebral hemorrhage patients and its clinical significance. Methods A total of 67 cases of hypertensive intracerebral hemorrhage in which hematoma volumes were between 30 ml to 50 ml were selected and divided into operative group （35 cases） and conservative group （32 cases）. Serum S-100 protein was detected with enzyme linked immunosorbent assay （ELISA） method. Results ①The concentrations of S-100 protein in conservative group were obviously higher than that in normal group within 21 days （ P 〈 0. 01 ） ; ②The concentrations of S-100 protein in operative group were higher than that in normal group within 7 days （P 〈0.01 ）, but there was no significant difference in concentration of S-100 in 15 day and 21 day and the nomal group （P 〉0. 05） ; ③There was no significant difference in the concentrations of S-100 protein between operative group and conservative group within 3 days, but the concentration of S-100 protein decreased rapidly and were obviously lower than that in conservative group in 15 day and 21 day （ P 〈 0.01 ）. Conclusion Evacuation of hematoma can reduce brain damage of hypertensive intracerebral hemorrhage.