粘附分子CD29和VEGF在胃癌组织中的表达及临床意义

The expression of adhesion molecular CD29 and VEGF in gastric carcinoma and its clinical significance

目的:探讨胃癌组织中粘附分子CD29的表达水平及其与血管内皮生长因子(vascular endothelial grouth factor,VEGF)的关系。方法:选择胃癌患者84例和浅表性胃炎患者48例对CD29和VEGF抗体SP法免疫组化染色。结果:84例胃癌标本中CD29有68例阳性,阳性率为80.9%,48例浅表性胃炎组织中有12例阳性表达,阳性率为25%(P<0.05)。胃癌中70例(83.3%)VEGF阳性表达。其中有63例VEGF与CD29共同表达。具显著正相关(P<0.05)。CD29的表达与患者的年龄、性别和肿瘤的大小、组织学类型及浸润深度无关。但与肿瘤的淋巴结转移具有显著的相关性(P<0.05)。结论:CD29可通过介导VEGF的表达促进肿瘤新生血管的形成,从而进一步促进肿瘤的生长和转移。

Objective：To study the relationship between expression of adhesion molecular CD29 in gastric carcinoma and vascular endothelial growth factor（VEGF）. Methods： Eighty four cases of gastric carcinoma and 48 cases of superficial gastritis were chosen to detect the CD29 and VEGF by spimmunohistrocbemical technique. Results： In the 84 cases of gastric carcinoma, 68 cases were CD29 positive, the positive rate was 80.9%. In the 48 cases of superfical gastritis, 12 cases were CD29 positive, the positive rate was 25% （ P 〈 0.05 ） , 70 cases of gastric carcinoma （83.3%） were VEGF positive, in which 63 cases coexpress VEGF and CD29, positive correlation existed statistically（ P 〈 0.05 ）. CD29 had no relationship with the age, sex, and the size, the histological type and the infiltration of tumour, but it had significantly relationship with lymph node metastasis of tumour（ P 〈 0.05）. Conclusion： CD29 could promote the growth of neovascular in tumour by introducing VEGF and encourage the growth and metastasis.