急性冠状动脉综合征患者C-反应蛋白升高与远期死亡率和心力衰竭的相关性分析

Relationship of C-reactive protein elevation with long-term mortality and heart failure in patients with acute coronary syndrome

目的评估C-反应蛋白(CRP)与急性冠状动脉综合征(ACS)患者远期预后的相关性。方法收集我院急诊ACS患者的资料并检测其CRP水平。入选患者随访3年,内容包括死亡,因急性心肌梗死(AMI)和充血性心力衰竭(CHF)而再次住院情况。结果共有446名患者入选,CRP升高的患者的死亡率和因CHF的再次住院率均高于CRP正常的患者(P<0.05)。校正心肌肌钙蛋白T(cTnT)水平后,急性期CRP>7.44 mg/L与发病后3年内的死亡率和因CHF再住院的风险增加仍显著相关。结论在胸痛早期就出现CRP升高的ACS患者的晚期死亡率和CHF风险增加。

Objective To assess the relationship of C-reactive protein （CRP） elevation with long-term outcomes and heart failure in patients with acute coronary syndrome （ACS）. Methods CRP level was measured in 446 ACS patients on admission in emergency department. All-cause mortality and rate of rehospitalisation for acute myocardial infarction （AMI） and congestive heart failure （CHF） were obtained for up to 3 years＇ follow up. Results Patients with CRP level above cut-off had a higher rate for death and CHF readmission. After adjusting for troponin T level, high CRP level （〉 7.44 mg/L） was still significantly associated with high risk for death and CHF. Conclusions ACS patients with early CRP level elevation have higher risk for death and heart failure.