艾滋病肺部并发症与CD_4 ^+T淋巴细胞水平的相关性

Correlation Between PCP in HIV/AIDS and CD_4 ^+T Lymphocyte Level

目的探讨艾滋病常见肺部并发症与CD4+T淋巴细胞的相关性。方法收集非洲博茨瓦纳Nyangabgwe医院>1万例HIV/AIDS患者的胸部平片,电脑随机抽取300例作为样本,根据CD4+T淋巴细胞计数,以200/mm3为界,将该样本分为两组,分析两组肺部并发症发病的情况,并以最具有特征性的卡氏肺囊虫性肺炎(PCP)为例,观察PCP治疗效果及其随访进行比较分析。结果HIV/AIDS最常见的肺部并发症有肺结核(PTB)、PCP、细菌性肺炎、肺门纵隔淋巴结肿大和卡波济肉瘤(KS)肺侵犯;当CD4+T淋巴细胞计数>200/mm3时肺部并发症少;当CD4+T淋巴细胞计数下降到≤200/mm3时,肺部并发症明显增多,且治疗效果差;两组之间差异有统计学意义(P<0.01)。结论艾滋病肺部并发症的发生发展及治疗效果与CD4+T淋巴细胞水平密切相关。

OBJECTIVE To explore the correlation between Pneumocystic carinii pneumonia（PCP） in HIV/AIDS and CD4^＋T-lymphocyte level.METHODS Totally 300 cases from more than 10 000 HIV/AIDS patients who were taken chest X-ray were sampled randomly.According to count of CD4^＋T-lymphocyte number,300 cases were divided into 2 groups： the count of CD4^＋T-lymphocyte number over than 200/mm3 was group A,while the other was group B.Analysis and comparison of lung complications in HIV/AIDS and follow-up survey of PCP curative effect in these 2 groups were done.RESULTS PTB,PCP,bacterial pneumonia Kaposi sarcoma（KS） and other lung ailmentd were the most common lung complications in HIV/AIDS.There were more lung complications and worse effect of PCP therapy in group B.There was significantly difference in group A and group B（P〈0.01）.CONCLUSIONS There is a direct correlation between PCP in HIV/AIDS and CD4^＋T-lymphocyte level.