244株铜绿假单胞菌的分布及耐药性分析

Distribution and Resistance of Pseudomonas aeruginosa:Analysis of 244 Strains

目的对2006年1-12月分离出的铜绿假单胞菌分布及耐药性进行分析。方法收集临床分离的铜绿假单胞菌进行培养鉴定,采用纸片扩散法(K-B法)或微量稀释法(MIC),结果根据美国临床实验室标准化委员会(NCCLS)相关文件判断。结果1年间分离出244株铜绿假单胞菌,对16种抗菌药物体外敏感试验结果显示,耐药率最高的是复方新诺明98.8%;其次是米诺环素、四环素、替卡西林/克拉维酸,分别为70.1%、58.6%、54.5%。结论加强对铜绿假单胞菌的耐药性连续监测,总结出医院各病区主要致病菌的耐药规律,减少耐药菌的产生有重要意义。

OBJECTIVE To investigate the distribution and resistance of Pseudomonas aeruginosa isolated during Jan-Dec 2006.METHODS The clinically isolated P.aeruginosa strains were collected cultured and identified by paper diffusing method or trace dilution method（MIC）,the results were evaluated according to the relevant documents of NCCLS of USA.RESULTS The in vitro susceptibility test of 244 P.aeruginosa isolates to 16 kinds of antibacterials indicated the resistance rate to SMZ was the highest（98.8%）,then to minocycline,tetracycline and ticarcillin/clavulanicacid（70.1%,58.6% and 54.5% respectively）.CONCLUSIONS To strengthen the continuous survezillance of drug resistance of P.aeruginosa,to sum up the resistance rules of main pathogens of departments in hospital and to reduce of production of resistant bacterica have the important significance.