前列汤治疗慢性盆腔疼痛综合征湿热瘀阻证临床研究

Treatment of chronic pelvic pain syndrome (TCM syndrome of damp-heat and blood-stasis obstruction) with Qianlie Decoction

目的评价前列汤治疗慢性盆腔疼痛综合征(CPPS)湿热瘀阻证的有效性和安全性。方法142例患者随机均分为2组:中药组口服前列汤,每日1剂,分2次服;对照组口服塞来昔布胶囊200mg,每日1次。疗程均为4周。治疗前后检测前列腺按摩液(EPS)中白细胞(WBC)和卵磷脂小体(SPL)计数,进行慢性前列腺炎症状评分(CPSI)及中医证候评分,分析治疗前后的差异并进行两组间比较。结果治疗后中药组CPSI评分较治疗前下降了11分,中医证候积分下降了14.14分,WBC下降了5.86;对照组CPSI评分较治疗前下降了9.85分,中医证候积分下降了9.80分,WBC下降了7.76。两组各项指标治疗前后的差值均有显著统计学意义(P<0.01),两组间差异无统计学意义(P>0.05)。两组治疗后SPL计数分级均明显升高(P<0.01),中药组优于对照组(P<0.01)。两组治疗CPPS湿热瘀阻证的疗效差异无统计学意义(P>0.05)。结论前列汤治疗CPPS湿热瘀阻证有效、安全。

Objective To evaluate the efficacy and safety of Qianlie Decoction in treating chronic pelvic pain syndrome （CPPS, TCM syndrome of damp-heat and blood-stasis obstruction）. Methods The patients （n = 142） were randomly divided into the treatment group treated with Qianlie Decoction （ 1 dose daily taken by 2 times）, and the control group was treated with Celecoxib Capsules （200 mg once daily）. The treatment course was for 4 weeks in two groups. The count of WBC and SPL in EPS were detected before and after the treatment. The scores of NIH-CPSI and TCM syndromes, and the difference between tow groups were compared and evaluated before and after the treatment. Results After the treatment In the treatment group the scores of NIH-CPSI was induced by 11, scores of TCM syndromes, by 14.14 and WBC, by 5.86. In the control group the scores of NIH-CPSI was induced by 9.85, scores of TCM syndromes, by 9. 80 and WBC, by 7. 76. The difference in all indexes in two groups was statistically significant before and after the treatment （ P 〈 0.01 ）. The difference between 2 groups was not significant statistically （ P 〉 0.05 ）. SPL counts were all increased significantly in two groups （ P 〈 0. 01 ）, and the result of the treatment group was better than that of the control group （P 〈 0.01 ）. The difference between two groups in the curative effect on CPPS （TCM syndrome of damp-heat and blood-stasis obstruction） was not statistically significant （ P 〉 0. 05 ）. efficacious and safe for treating CPPS （TCM syndrome of damp-heat Qianlie Decoction is and blood-stasis obstruction）.