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己酮可可碱对内毒素血症大鼠心肌TLR4与TNFα mRNA表达影响及机制研究 被引量：2

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摘要 目的:研究己酮可可碱(pentoxifylline,PTX)对内毒素血症(endotoxemia,ETM)大鼠心肌组织Toll样受体4(toll like receptor4,TLR4)及肿瘤坏死因子α(tumor necrosis factor alpha,TNFα)mRNA表达的影响,探讨PTX在ETM中对急性心肌损伤的保护作用。方法:实验分空白对照组,ETM组,PTX组;ETM经尾静脉注射脂多糖(lipopolysaccharide,LPS)5mg/kg,运用逆转录-聚合酶链反应(RT-PCR)检测心肌组织TLR4和TNFαmRNA的表达。结果:ETM组心肌组织中TLR4与TNFα表达均较正常对照组显著增强(P<0.001);注射PTX后心肌组织中TLR4与TNFαmRNA表达分别比ETM组显著减少(P<0.01)。结论:PTX可通过抑制ETM心肌组织TLR4功能及其介导的信号转导,抑制促炎症因子表达,对ETM心肌损伤起保护作用。
作者 顾建军 叶记录 孙华
机构地区 泰州市人民医院ICU 南通大学第二附属医院ICU
出处 《心肺血管病杂志》 CAS 2007年第4期227-228,232,共3页 Journal of Cardiovascular and Pulmonary Diseases
关键词 内毒素血症 TOLL样受体4 肿瘤坏死因子α 己酮可可碱 动物试验 大鼠
分类号 R318 [医药卫生—生物医学工程] R734.2 [医药卫生—肿瘤]
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参考文献10

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共引文献8

同被引文献16

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引证文献2

二级引证文献10

心肺血管病杂志
2007年 第4期

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