dl-四氢巴马汀对实验性脑血栓形成及体外血小板聚集的抑制作用

Effects of dl tetrahydropalmation on rabbit platelet aggregation and experimental cerebral thrombosis in rats

目的：观察ｄｌ－四氢巴马汀（ｄｌ－ＴＨＰ）对大鼠实验性脑血栓形成的影响。并观察体外ｄｌ－ＴＨＰ对二磷酸腺苷、花生四烯酸和胶原诱导的兔血小板聚集的影响。方法：采用经大鼠颈动脉顺行注射复合血栓诱导剂（二磷酸腺苷、凝血酶和肾上腺素）造成的脑血栓模型。结果：ｄｌ－ＴＨＰ（１５、７．５ｍｇ·ｋｇ－１）ｉｖ对大鼠实验性脑血栓形成有明显的抑制作用。ｄｌ－ＴＨＰ对二磷酸腺苷、花生四烯酸和胶原诱导的兔血小板聚集均有抑制作用，并呈剂量依赖关系。结论：其作用可能是通过拮抗钙离子的作用而产生。

AIM:The effects of dl tetrahydropalmation on rabbit platelet aggregation and experimental cerebral thrombosis in rats were studied. METHODS:The co thrombus inducer, a mixture of adenosine diphosphate, thrombin and epinephrine, was injected into rat carotid artery to induce cerebral thrombosis. RESULTS: dl tetrahydropalmation at the dosage of 15 mg·kg -1 and 7 5 mg·kg -1 inhibited the experimental cerebral thrombosis and rabbit platelet aggregation induced by adenosine diphosphate, arachidonic acid with a dose dependent manner in vitro. CONCLUSIONS:The mechanism of these effects might be related to calcium iron antagonism.