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载脂蛋白E基因多态性与动脉粥样硬化性脑梗塞的关系 被引量:17

The relations between polymorphisms of apolipoprotein E gene and atherosclerotic cerebral infarction
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摘要 目的探讨载脂蛋白(Apo)E基因多态性与动脉粥样硬化性脑梗塞(ACI)的关系。方法用聚合酶链反应(PCR)技术检测了中国沈阳籍汉族健康人100名和ACI患者47例的ApoE基因HhaI多态性及血脂、脂蛋白含量。结果ACI患者组ApoE基因型ε3/4的频率为27.7%,明显高于对照组。ACI患者组血清低密度脂蛋白胆固醇(LDL-C)、脂蛋白(a)[Lp(a)]明显高于对照组,ApoAI则明显低于对照组。对照组和ACI患者组中ApoE基因型ε3/4的血清LDL-C均显著高于ε3/3。结论ApoE基因型ε3/4与ACI的发生相关;等位基因ε4可能是ACI的一种遗传易感性因子。 Objective To study the relations between the polymorphisms of apolipoprotein E (Apo E) and atherosclerotic cerebral infarction (ACI). Methods The polymerase chain reaction (PCR) technique was used to study the polymorphisms of Apo E gene and allele frequencies in 100 age matched Chinese healthy controls and 47 patients with ACI. The levels of the lipid and lipoproteins were also compared between the cases with ACI and the controls. Results The prevalence of genotype ε3/4 was 27.7% in the ACI group, which was significantly higher than that (12.0%) in the control group ( P <0.05). The serum levels of low density lipoprotein cholesterol (LDL C) and lipoprotein (a) in the ACI group were significantly higher than those in the control group ( P <0.01). The level of LDL C was higher in the group of the controls and ACI with genotype of ε3/4 than in the group with genotype of ε3/3. Conclusion Genotype of ε3/4 may contribute to the development of ACI in Chinese and allele ε 4 seemd to be a genetic susceptible factor in ACI.
出处 《中华神经科杂志》 CAS CSCD 1997年第4期236-239,共4页 Chinese Journal of Neurology
关键词 动脉粥样硬化 脑梗塞 基因 载脂蛋白E类 多态性 Atherosclerosis Cerebral infarction Genes Apolipoproteins E
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参考文献5

  • 1顾牛范,中华医学遗传学杂志,1996年,13卷,8页
  • 2向光大,中华医学遗传学杂志,1995年,12卷,197页
  • 3郭夏玲,北京医学,1989年,11卷,149页
  • 4解用虹,中华医学杂志,1989年,69卷,585页
  • 5解用虹,天津医药,1988年,16卷,651页

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