拉米夫定联合膦甲酸钠治疗慢性乙型重型肝炎25例

Lamivudine combined with foscarnet sodium in treating chronic severe hepatitis B in 25 patients

目的探讨拉米夫定联合膦甲酸钠对慢性乙型重型肝炎的疗效。方法50例患者按入院先后分成2组,治疗组25例,对照组25例。2组病例均给予内科综合治疗,治疗组在内科综合治疗基础上加用拉米夫定100mg,po,qd,膦甲酸钠3.0g,iv gtt,qd。观察2组治疗前后临床症状、肝功能指标及并发症的变化,并比较有效率。结果治疗组有效率76%,对照组有效率36%,2组对比有统计学意义(P<0.05)。结论在内科综合治疗基础上联合拉米夫定、膦甲酸钠能有效提高慢性重型肝炎患者的疗效。

AIM To observe the clinical effects of lamivudine combined with foscamet sodium in treating patients with chronic severe hepatitis B（CSH）.METHODS Fifty CSH patients were derided into therapeutic group（n = 25） and control group（n = 25）according to the admission date.Both groups were treated with same ordinary method,Lamivudine 100 rng by oral administration and foscamet sodium 3.0 g by intravenous transfusion were given once a day in the therapeutic group.The changes of manifestation,liver function and complication were observed.The eflqcieney rate was also compared between 2 groups.RESULTS There is a significant difference in the efficiency rate between therapeutic group and control group（76%vs 36%,P〈0.05）.CONCLUSION The efficiency rate of CSH treated with lamivudine and foscarnet sodium can be increased greatly.