期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

苏木醇提物对重症肌无力患者干扰素-γ水平的影响

Effects of ethanol extracts of Caesalpinia Sappan L on IFN-γ in myasthenia gravis
下载PDF
导出
摘要 目的观察苏木醇提物治疗重症肌无力(MG)患者的乙酰胆碱受体抗体(AChRab)、干扰素-γ(IFN-γ)水平变化,探讨苏木醇提物治疗MG可能的免疫机制。方法采用ELISA法对苏木治疗组和常规治疗组MG患者治疗前、后及30例正常对照组外周血AChRab、IFN-γ水平进行检测并作分析。结果①苏木治疗组与常规治疗组MG患者血清ACh-Rab水平治疗前后均较正常对照组显著升高(P<0.05),苏木治疗组与常规治疗组MG患者治疗前血清AChRab水平比较差异无显著性意义(P>0.05),而治疗后差异有显著性意义(P<0.05);②苏木治疗组与常规治疗组MG患者血清IFN-γ水平治疗前后均较正常对照组显著升高(P<0.05),苏木治疗组与常规治疗组MG患者治疗前血清IFN-γ水平比较差异无显著性意义(P>0.05),治疗后差异有显著性意义(P<0.05)。结论苏木醇提物可能通过降低IFN-γ水平从而减少血中AChRab的生成,缓解肌无力症状。 Objective This study examined the changes of acetylcholine receptor antibody （AChRab） and γ-interferon （IFN-γ） in patients with myasthenia Davis treated with ethanol extracts of Caesalpinia Sappan L, in order to explore possible immunological mechanisms of ethanol extracts of Caesalpinia Sappan L for the treatment of myasthenia gravis. Methods Blood levels of AchRab and IFN- γwere measured using enzyme-linked immunosorbentassay （ELISA） in 69 patients with myasthenia Davis, including an ethanol extracts of Caesalpinia Sappan L therapy group （ n = 34） and a conventional therapy group （ n = 35 ） and in 30 normal control. Results Blood levels of AchRab and IFN-γin the ethanol extracts of Caesalpinia Sappan L therapy and conventional therapy groups were signifi- candy higher than in the normal control group （ P 〈 0.05 ） before and after treatment. There were no significant differences in the blood levels of AchRab and IFN-γ between the two therapy groups before treatment, but after treatment the blood levels of AchRab and IFN-γin the ethanol extracts of Caesalpinia Sappan L therapy group were significantly lower than those in the conventional therapy group （P 〉 0.05 ）. Conclusions Ethanol extracts of Caesalpinia Sappan L relieve amyasthenia possibly through reducetion of blood levels of IFN-γ and AchRAb in patients with myasthenia gravis.
作者 李新军 高力 熊跃均
机构地区 四川省自贡市第四人民医院
出处 《国际神经病学神经外科学杂志》 2007年第6期507-509,共3页 Journal of International Neurology and Neurosurgery
关键词 重症肌无力 苏木醇提物 乙酰胆碱受体抗体 干扰素-Γ myasthenia Davis ethanol extracts of Caesalpinia Sappan L AchRAb IFN-γ
分类号 R746.1 [医药卫生—神经病学与精神病学] R512.62 [医药卫生—内科学]
  • 相关文献

参考文献6

  • 1Saridi-Linardaki L, Trakas N, Mamalaki A, et al. Specific immunoadsorption of the autoantibodies from myasthenic patients using the extracellular domain of the human muscle acetylcholine receptor alpha-subunit. Development of an antigenspecific therapeutic strategy. Neureimmunol, 2005, 159 ( 1 - 2) : 183-191.
  • 2Poea-Guyon S, Christadoss P, Le Panse R, et al. Effects of cytokines on acetylcholine receptor expression: implications for myasthenia gravis. Immunol, 2005, 174(10) : 5941-5949.
  • 3Poussin MA, Fuller CE, Reyes VE, et al. Supressed clinical experimental autoimmune myasthenia gravis in bm-12 mice is lined to reduced intracelhr calcium medilization and IL-10, 1FN-ganuna release by acetylcholine receptor specific T cells. Neuroimmunol, 2003 , 139 ( 1-2 ) : 104-110.
  • 4Tuzun E, Meriggioli MN, Rowin J, et al. Myasthenia gravis patients with low plasma IL-6 and IFN-gamma benefit from etanercept treatment. J Autoimmun, 2005 , 24 ( 3 ) : 261 - 268.
  • 5Milani M, Ostlie N, Wang W, et a l. T cells and cytokines in the pathogenesis of acquired myasthenia gravis. Ann N Y Acad Sci, 2003, 998(9) : 284-307.
  • 6陈秀,胡长林.树突状细胞在多发性硬化发病中的作用[J].国际神经病学神经外科学杂志,2006,33(6):543-546. 被引量：1

二级参考文献23

  • 1Ludewig B,Junt T,Hengartner H,et al.Dendritic cells in autoimmune disease.Curr Opin Immunol,2001,13 (6):657-662.
  • 2Pashenkov M,Huang YM,Kostulas V,et al.Two subsets of dendritic cells are present in human cerebrospinal fluid.Brain,2001,124(Pt3):480-492.
  • 3Pashenkov M,Teleshova N,Kouwenhoven M,et al.Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis.Clin Exp Immunol,2002,127(3):519-527.
  • 4Sorensen TL,Tain M,Jensen J,et al.Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients.J Clin Invest,1999,103(6):807-815.
  • 5Pashenkov M,Teleshova N,Link H.Inflammation in the central nervous system:the role for dendritic cells.Brain Pathol,2003,13(1):38-51.
  • 6Serafini B,Columba-cabezas S,Di Rosa F,et al.Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis.Am J pathol,2000,157(6):1991-2002.
  • 7Plumb J.CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions.Multi Scler,2003,9(2):142-147.
  • 8Barbara S,Barbara R,Roberta M,et al.Dendritic cells in multiple sclerosis lesions:maturation stage,myelin uptake,and interaction with proliferating T cells.J Neuropathol Exp Neurol,2006,65(2):124-141.
  • 9Greter M,Hepper FL,Lemos MP,et al.Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Nat Med,2005,11(3):328-334.
  • 10Elena A,Maria ER,Elena G,et al.Astrocytes produce dendritic cell-attracting chemokines in vitro and in multiple sclerosis lesions.J Neuropathol Exp Neurol,2005,64 (8):706-715.
国际神经病学神经外科学杂志
2007年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部