布鲁氏菌胞内生存机制研究进展

Advances in the Research on the Brucella Intracellular Life

布鲁氏菌是一种胞内寄生菌,可以在专业和非专业吞噬细胞内生存和复制。当布鲁氏菌与细胞接触时,细菌可以通过受体分子进入细胞。布鲁氏菌在细胞内首先定位于早期吞噬体,然后,在胞内改变其运输方向,最终抵达其胞内复制部位内质网,开始大量复制。这种复制既不影响细胞的基本功能,也不诱导细胞的损伤。主要综述了布鲁氏菌对细胞的侵袭、胞内运输和复制的相关研究进展。

Brucella organisms are facultative intracellular bacteria capable of surviving inside professional and non-professional phagocytes. Upon cell contact the bacteria is internalized via receptor molecules. Once inside cells, Brucella localizes in early phagosomes, where it avoids fusion with late endosomes and lysosomes. Then, the bacterium redirects its trafficking to autophagosomes and finally reaches the endoplasmic reticulum, the replicating niche. Once inside the endoplasmic reticulum, Brucella extensively replicates without restricting basic ceUular functions or inducing damage to cells. Invasion, intraceUular trafficking and replication of Brucella organisms in professional and non-professional phagocytes and the molecular determinants involving Brucella intracellular life are reviewed in this article.