阿西美辛海藻酸钙凝胶微丸释药影响因素考察

Study on the release properties of acemetacin calcium alginate gel beads

目的:考察阿西美辛海藻酸钙凝胶微丸的释药机制。方法:采用滴制法制备阿西美辛海藻酸钙微丸,考察海藻酸钠浓度,钙离子浓度,投药量,滴头直径大小对药物释放的影响。结果:海藻酸钠浓度增加,钙离子浓度增加,滴头直径增加,释药速率减慢。结论:在体外释放度实验中,阿西美辛海藻酸钙凝胶微丸具有良好的缓释作用,海藻酸钙凝胶微丸是一种非常有潜力的药物载体。

OBJECTIVE To investigate the release properties of acemetacin calcium alginate gel beads. METHODS Acemetacin calcium alginate gel beads were prepared by the dropping method. The effects of several factors such as the concentration of sodium alginate and calcium ion, drug loading, inner diameter of needle on drug release properties were investigated respectively. RESULTS Increasing the concentration of sodium alginate or calcium ion, the inner diameter of needle, the rate of drug release decreased. CONCLUSION Alginate gel beads shows good sustained-release properties.