原发性肝癌患者门静脉血及外周静脉血T细胞亚群和IL-2R表达的对比研究

A comparative study of T-lymphocyte subsets and expression of IL-2R between portal venous blood and peripheral venous blooding patients with primary Liver cancer

By means of inderected immunofluorescence antibody assay,we investigated T-lymphocyte subsets and expression of IL-2R of portal venous blood and peripheral wnousblood in partents with primary liver cancer (PLC), non-maligbnancy patients as coutral.The results showed that ①In the group of PLC,CD3+ Lymphocytes and CD4+/CD8+ ratio inportal venous blood were markedly decreased,compared with that in peripheral venous blood(D＜0. 001 ) ②The PHA - stimulated expression of IL - 2R of portal venous mononuclearcells was significantly lower than that of peripheral venous’s (D＜0. 05 ), but the group ofPLC in particular (D＜0. 0025). The mechanism which cellular immune function of portal venous blood was much lower than that of peripheral venous blood in patients with PLC wasunclear. We believed that spleen and gastrdenteric system may play an impartant role.