摘要
基因芯片与SELDI-TOF蛋白质芯片技术在卵巢癌早期诊断中得到了广泛应用,但SELDI-TOF蛋白质芯片技术存在的内在缺陷(测试结果的不精确性以及数据分析技术的不成熟性)。改进卵巢癌早期诊断的研究策略有:(1)把基因芯片技术和SELDI-TOF蛋白质芯片技术结合起来进行卵巢癌早期诊断研究;(2)采用MALDI-TOF技术来实现血清蛋白质谱的测试;(3)开发更有效的数据挖掘算法。
Based on surface enhanced laser desorption/ionization time-of-flight （SELDI-TOF） protein-chip technology to study early diagnosis of ovarian cancer, are drowning extensive attention and debate. So we review the advances of early diagnosis of ovarian cancer which are based on microarray and protein-chip technology respectively, pointing out that the imprecise of the testing results based on SEL- DI-TOF technology and the methodology shortcoming of data analysis are the main reasons of irreproduc- ibility of the experiments. Aims at the early diagnosis of ovarian cancer, three suggestions are put forward：（1） to combine the microarray and SELDI-TOF protein-chip technology;（2） to employ MALDITOF technology to test the mass spectrum of serum protein and （3） to develop more efficacious algorithms.
出处
《国际病理科学与临床杂志》
CAS
2007年第6期489-492,共4页
Journal of International Pathology and Clinical Medicine
基金
教育部留学归国人员启动基金(教外司留[2005]383号)~~
关键词
表面增强激光解吸离子化飞行时间
数据挖掘
卵巢癌
基因芯片
蛋白质芯片
surface enhanced laser desorption/ionization time-of-flight （SELDI-TOF）
data mining
ovarian cancer
microarray
protein chip
