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SHP-1基因与白血病/淋巴瘤

SHP-1 gene and leukemia/lymphoma
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摘要 SHP-1基因是近年来发现的抑癌基因,通过对下游信号蛋白分子磷酸酪氨酸脱磷酸化而终止、消弱细胞生长信号或激活凋亡信号负调控造血细胞的分化、发育和增殖。启动子甲基化是SHP-1基因沉默的主要机制,SHP-1表达降低及缺如与造血细胞的恶性转化及增殖优势表型有密切的关系,并与白血病/淋巴瘤的形成、侵袭性及预后相关。 SHP-1 is a tumor suppressor gene found in recent years. SHP-1 negatively modulates the differentiation, growth and proliferation of hematopoietic cells by dephosphorylating the downstream proteins, which subsequently either terminate or attenuate the activated growth signal or activate apoptosis pathway. Aberrant promoter methylation is the major/nechanism of SHP-1 gene silencing, The decreased levels of SHP-1 protein and mRNA were associated with the transformation and growth advantage of hematopoietic cells, and were related to the onset, aggression, and prognosis of leukemia/lymphoma.
作者 李英华 罗建民
机构地区 哈励逊国际和平医院血液科 河北医科大学第二医院血液科
出处 《国际病理科学与临床杂志》 CAS 2007年第6期507-510,共4页 Journal of International Pathology and Clinical Medicine
基金 河北省自然科学基金(C200500074) 衡水市科技局科学技术研究与发展计划项目(06020Z)~~
关键词 SHP-1 抑癌基因 基因沉默 甲基化 SHP-1 tumor suppressor gene gene silencing methylation
分类号 R733 [医药卫生—肿瘤]
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参考文献21

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二级参考文献8

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国际病理科学与临床杂志
2007年 第6期

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