308例老年妇女乳腺癌临床病理特征、甾体激素受体水平与预后的关系

The correlation of clinicopathologic features, hormone receptor level with the prognosis of breast cancer in 308 elderly women

目的探讨老年妇女乳腺癌的临床病理特点、甾体激素受体水平与预后的关系。方法分析并复查３０８例的病理组织学、临床病案资料和系统的随访资料。其中１３０例肿瘤标本采用葡聚糖活性炭饱和分析法检测雌激素受体（ＥＲ）和孕激素受体（ＰＲ）。结果３０８例中，Ⅰ期８２例，Ⅱ期１４７例，Ⅲ期６６例，Ⅳ期１３例。腋下淋巴结转移率３５．７％。术后５年生存率为７０．８％，１０年为５０．５％。ＥＲ阳性率６６．９％，ＰＲ阳性率４０．０％。生存率随ＴＮＭ分期的增级而降低（Ｐ＜０．０１），病死率与ＥＲ、ＰＲ水平明显相关（Ｐ＜０．０５）。结论老年妇女乳腺癌经外科手术治疗后有较高的５年、１０年生存率，其预后与肿瘤大小、腋下淋巴结转移率、甾体激素受体水平明显相关。

Objective To study the relationship between the clinicopathologic features, hormone receptor level of breast cancer and the prognosis in aged patients. Methods The clinicopathologic and follow up data of the 308 cases were reviewed. Tumor specimens in 130 patients were subjected to hormone receptor analysis by a dextran coated charcoal technique. Results Of the 308 cases, 82 cases were in stage Ⅰ, 147 cases in stage Ⅱ,66 cases in stage Ⅲ,and 13 cases in stage Ⅳ. Metastatic rate (axillary lymph nodes) was 35 7%. The overall postoperative 5 and 10 year survival rates were 70 8% and 50 5%, respectively. Estrogen receptor and progesterone receptor positive rates were 66 9% and 40.0%, respectively. The survival rate decreased with the increasing grade of TNM ( P <0 01). The mortality rate of the breast cancer was related to the clinical stage and the hormone receptor level( P <0.05). Conclusions There was a relatively good prognosis in this series. The size of tumor, number of metastatic nodes and hormone receptor level were ralated to the prognosis.