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老年多发性骨髓瘤患者血清白细胞介素-2的检测及临床意义

Measurement of serum interleukin 2 in elderly patients with multiple myeloma and its clinical implication
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摘要 目的检测老年多发性骨髓瘤(MM)患者血清白细胞介素-2(IL-2)含量,分析其临床意义。方法用固相放射免疫分析(RIA)法检测44例初诊老年MM患者、20例健康老年人和40例健康青中年人血清IL-2含量,随访患者3年的存活状况。结果MM患者血清IL-2为8.11±2.54μg/L,显著高于老年健康对照组的2.68±0.61μg/L(P<0.01)。血清IL-2≥5μg/L的患者3年生存率显著提高。血清IL-2与血清β2微球蛋白(β2-MG)有关,血清IL-2≥5μg/L的患者,β2-MG皆<6mg/L。结论血清IL-2的检测可作为估计MM预后的一项指标。 Objective To find the level of serum interleukin 2(IL 2) in elderly patients with multiple myeloma (MM) and its clinical implication. Methods Serum IL 2 level was detected in 44 newly diagnosed MM patients, 20 elderly healthy controls and 40 young healthy controls with radioimmunoassay (RIA) methods.The survival period of the patients was then followed. Results Serum IL 2 level in MM patients was 8 11±2 54μg/L, but that in elderly healthy controls was 2 68±0 61 μg/L . A statistically significant difference was observed between the patients and the elderly healthy controls ( P <0 01).Three year survival rate in patients with serum IL 2≥5μg/L was higher than in those with IL 2<5μg/L. Furthermore, all patients with serum IL 2≥5μg/L had serum β 2 MG level<6mg/L. By using these two parameters, three groups could be identified and the survival duration was different among the three groups. Conclusions These data indicated that serum IL 2 levels could be used as a reliable factor to predict the prognosis of MM.
出处 《中华老年医学杂志》 CAS CSCD 北大核心 1997年第4期223-225,共3页 Chinese Journal of Geriatrics
关键词 白细胞介素-2 血液 多发性骨髓瘤 检测 interleukin 2 multiple myeloma
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参考文献2

  • 1赵武述,中华核医学杂志,1990年,10卷,55页
  • 2蔡则骥,中华血液学杂志,1987年,8卷,580页

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