RNAi在原发性肝癌治疗中的研究进展

Progress in treatment of hepatocarcinoma with RNA interference

RNA干扰(RNA interfcrence),即RNAi,是一种在真核生物体中广泛存在的通过双链RNA分子在mRNA水平上诱导特异性序列基因表达部分或完全抑制的过程.本文主要对RNAi的机制及其在肝癌研究治疗中的应用作一综述.

RNA interference （RNAi） is a process that exists widely in eukaryotes. Silencing of a target gene is induced by a double-stranded RNA （dsRNA） at the post-transcription level, partially or fully. This paper is to review the main mechanisms of RNAi and the progress in hepatocarcinoma treatment with RNAi.