中国人脑内平野小体的初步观察

A study on Hirano body in brains of Chinese

目的观察我国人脑海马平野小体改变情况，为研究国人脑老化及Ａｌｚｈｅｉｍｅｒ病提供参考。方法２３９例非痴呆尸检脑及６例Ａｌｚｈｅｉｍｅｒ病脑，自海马处取材、制片、ＨＥ染色，光镜下观察锥体细胞Ｈ１、Ｈ２、Ｈ３段及腔隙层平野小体。结果Ｈ２、Ｈ３段平野小体极少，主要见于海马锥体细胞Ｈ１段及腔隙层。在Ｈ１段，６０岁以前者其阳性率为１６．１％，此后逐年增加，至８０岁以上达４５．５％。对腔隙层观察结果表明，阳性率（３６．９％）较锥体细胞Ｈ１段（２４．７％）高（Ｐ＜０．０５），其阳性率高峰在２０～５９岁之间。海马锥体细胞Ｈ１段最早出现平野小体者为８岁儿童，腔隙层于２个月幼婴，均早于国外。结论海马锥体细胞Ｈ１段平野小体与增龄有关，腔隙层出现平野小体难以作为增龄标志。

Objective The number of Hirano body in hippocampus increases with aging. The aim of this study is to know the incidence of Hirano body in brains of Chinese people and patients with Alzheimers disease. Methods Brains from 239 consecutive autopsies and 6 cases of Alzheimers disease in Chinese were studied with routine pathologic technique. Results Hirano bodies were found mainly in H 1 segment of hippocampus, but rarely in H 2 and H 3 segments. The incidence was 16 1% in people before 60 years old and 45 5% after 80 years, increasing apparently with aging. As to the incidence of Hirano bodies in stratum lacuneum, it was 36 9%, being higher than that of 24 7% in the H 1 segment of hippocampus neurons( P <0 05). The highest incidence of Hirano bodies in stratum lacuneum was found in people between 20 to 59 years old. The youngest one with Hirano body in the H 1 pyramidal cells was an 8 year old boy and the one with Hirano body in stratum lacuneum was even younger, being a 2 month old baby. Our findings are similar to those of the western countries, but the incidence of Hirano body is slightly lower than that reported in the literature. Conclusions The Hirano body in H 1 segment of hippocampus neurons is of more significance than that in the stratum lacuneum for evaluation of aging.