阻塞性睡眠呼吸暂停低通气综合征与促红细胞生成素的相关性研究

Correlation of Obstructive Sleep Apnea Hypopnea Syndrome and Erythropoietin

目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OS-AHS)患者血清促红细胞生成素(erythropoietin,EPO)的水平、悬雍垂腭咽成形术(uvulopalatopharyngoplasty,UP-PP)的疗效以及对 EPO 水平的影响。方法对经多导睡眠仪监测诊断的59例 OSAHS 患者行 UPPP。采用放射免疫法测定 OSAHS 患者术前、术后及38例健康对照组的血清 EPO 水平,观察呼吸暂停低通气指数、体质量指数、血氧饱和度、EPO 水平的变化。结果 OSAHS 患者术前术后呼吸暂停低通气指数、体质量指数、血氧饱和度比较差异均有统计学意义(P<0.05)。OSAHS 患者 EPO 水平术前术后比较差异有统计学意义(P<0.05);术前 EPO 水平与对照组比较,差异有统计学意义(P<0.05),术后 EPO 水平与对照组比较,差异无统计学意义(P>0.05)。结论 OSAHS 患者血清 EPO 水平较对照组偏高,并与睡眠呼吸暂停低通气指数有关。UPPP 是治疗 OSAHS 的有效手段,可降低血清 EPO 水平。(中国眼耳鼻喉科杂志,2007,7:369-371)

Purlmse To investigate the serum erythropoietin （EPO） levels in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） and the therapeutic effect of uvulopalatopharyngoplasty （UPPP） on the EPO levels. Methods Fifty-nine patients with OSAHS based on the polysomnography were treated with UPPP. Preoperative and postoperative serum EPO levels of the patients and the serum EPO of 38 healthy persons were collected. Preopera- tive and postoperative apnea hypopnea index （AHI） ,body mass index （BMI）, arterial oxygen saturation（ SaO2 ） and the EPO level were detected respectively. Results Postoperative AHI, BMI, SaO2 and EPO were all significantly different from the preoperative＇s（ P 〈 0.05 ）. The preoperative EPO levels were significantly different from that of control normal adults（ P 〈 0.05 ）. But the postoperative EPO levels had no significant difference （ P 〉 0.05 ）. Conehltsions The level of EPO in OSAHS patients was higher than that in healthy controls and was correlated with AHI. The UPPP was an effective treatment for OSAHS possibly by lowering the EPO level in the serum.