血浆脂联素水平与冠心病的相关性

Plasma adiponectin concentrations correlated with coronary heart disease

目的观察冠心病患者血浆脂联素水平,并探讨血浆脂联素水平与冠心病间的关系。方法经冠状动脉造影证实的冠心病患者共219例,对照组187例,采用Adiponectin ELISA试剂盒检测血浆脂联素水平,检测空腹血糖(BS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C);计算体重指数。结果冠心病组患者的脂联素水平(6.3vs 12.6,P<0.01)显著低于对照组;Spearman偏相关分析显示经年龄、性别校正后脂联素水平与BS、SBP、LDL-C、TG呈负相关,与HDL-C呈正相关;多元logistic回归分析显示脂联素水平与冠心病及其主要危险因子独立相关。结论冠心病患者血浆脂联素水平降低,可能是冠心病的一个新的独立危险因子。

Objective To test plasma adiponectin concentrations of coronary heart disease（CHD） patients and evaluate whether plasma adiponectin concetrations were associated with CHD. Methods Plasma adiponectin concentrations were measured using adiponectin ELISA kit in 219 casese CHD patients confirmed by coronary angiography and 187 casese angiographically negative pa2 tients. Plasma concentrations of fasting blood sugar （BS）, total cholesterol （TC）, triglycerin （TG）, low density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HDL-C） were measured by routine method. Body mass index was calculated. Results Plasma adiponectin concentrations in CHD patients were significantly lower than those in the control subjects. Spearman partial correlation analysis showed that adiponectin was significantly negatively correlated with BS, systolic blood pressure, LDL-C and TG,and positively correlated with HDL-C after adjustment for age and sex. Multiple logistic regression analysis showed that plasma adiponectin concentrations were independently correlated with CHD and its main risk factors. Conclusion Plasma adiponectin concentrations decrease in CHD patients and might be an new independent risk factor of CHD.