摘要
用交联剂乙二醛或戊二醛直接交联制备了壳聚糖-β-环糊精交联物,用IR对产物结构进行了确证。用电镜扫描研究了壳聚糖-β-环糊精微粒的表面结构,表明壳聚糖-β-环糊精交联微粒呈多孔性表面。环糊精在壳聚糖上的固载量受β-环糊精/壳聚糖重量投料比,交联剂用量,反应体系的酸度和温度影响。结果表明采用乙二醛做交联剂时,温度为85℃,重量投料比(β-CD/chitosan)为6∶1,摩尔比(乙二醛/β-CD)4∶1,β-CD的固载量最大。采用戊二醛做交联剂时,温度为85℃,重量投料比(β-CD/chi-tosan)为6∶1,摩尔比(戊二醛/β-CD)3∶1,β-CD的固载量最大。这种壳聚糖-β-环糊精树脂对非结合型胆红素有较高的吸附能力。
A cyclomaltoheptaose-β-Cyclodextrin （β-CD） crosslinked chitosan derivative via glyoxal or glutaraldehyde was prepared. The structures of β-CD crosslined chitosan with glyoxal （Ⅰ） or glutaraldehyde （Ⅱ） were characterized by IR spectra. The surface morphology of the β-CD crosslinked chitosan particles was examined using a scanning electron microscope. Chitosan-linked cyclodextrin beads have highly porous structure. The immobilization capacity of β-CD on chitosan was affected on the weight ratio of β-CD/chitosan, the utilization amount of crosslinking agent,the acidity of the reaction system and the temperature. The results showed that the maximum amounts of β- CD was immobilized into chitosan by glyoxal under the optimum conditions： temperature 80℃, weight ratio （β-CD/ chitosan）6 ： 1,molar ratio （glyoxal/β-CD） 4 ： 1,and by glutaraldehyde： temperature 85℃, weight ratio（β-CD/chitosan） 6 ： 1, molar ratio （glutaraldehyde/β-CD） 3 ： 1. The β-Cyclodextrin （β-CD） crosslinked chitosan derivative as adsorbent has high adsorption capacity for unconjugated bilirubin.
出处
《科技通报》
2008年第1期1-4,10,共5页
Bulletin of Science and Technology
基金
省科技厅资助项目(981106229)
