头孢西丁钠在4种输液中的稳定性考察

A study on the stability of cefoxitin sodium in four infusions by HPLC

目的：考察注射用头孢西丁钠与4种输液配伍的稳定性，为临床合理用药提供科学依据。方法：在25℃将头孢西丁钠分别与0.9％氯化钠注射液、5％葡萄糖注射液、葡萄糖氯化钠注射液、木糖醇注射液配伍，在12h内用高效液相色谱法测定头孢西丁钠的含量。结果：头孢西丁钠在50～800μg／mL检测浓度范围内呈良好线性关系（r=0．9998），平均回收率为（99．7±1．1）％；日内差RSD≤1．4％（n=5），日间差RSD≤1．9％（n=5）。头孢西丁钠与4种输液配伍12h内含量〉93％。结论：头孢西丁钠与4种输液在25℃、12h内配伍稳定。

Objective：To study the stability of eefoxitin sodium for injection in four kinds of infusion solutions for the rational use of drugs in clinic. Methods：The cefoxitin sodium was mixed with four kinds of infusions, and the contents of cefoxitin sodium were determined by HPLC at 25 ℃ within 12 hours. Results： The assay was linear over the concentration range of 50 - 800 μg/mL （ r = 0.9998）. The average recovery was 99.7% ±1.1%. Intra-day and inter-day precision showed coefficients of variation within 1.4% （ n = 5） and 1.9% （ n = 5） over the three concentration levels. The four kinds of infusion solutions containing eefoxitin sodium retained more than 93% of the initial levels within 12 hours. Conclusions：Cefoxitin sodium in the four kinds of infusion solutions can be used for 12 hours.