土壤中氟喹诺酮类药物残留的生态效应及归宿

Ecological Effects and Fate of Fluoroquinolones Residues in Soil

氟喹诺酮类药物是人工合成的高效广谱抗菌药,对细菌的DNA螺旋酶具有选择性抑制作用,因其具有良好的药物动力学特性及治疗效果,临床应用非常广泛,但同时也引起环境污染。本文综述了氟喹诺酮类药物的理化特性及其对环境的影响,土壤中残留氟喹诺酮类药物的检测以及氟喹诺酮类药物污染土壤的生物修复。

Fluoroquinolones are synthetic antimicrobial agents that are active against a broad spectrum of pathogenic Gram-negative and -positive bacteria by selectively inhibiting DNA gyrase and used in a wide variety in clinic because of their good pharmic kinetics and curing effects, thus causing environmental pollution. The physicochemical characteristics of fluoroquinolones and their environmental effect, identification, monitoring and bioremediation in soil were summarized in this paper.