摘要
用ＤＮＡ－ＲＮＡ斑点杂交技术分析４０例急性白血病细胞中ｐ５３、ｃ－ｍｙｃ基因的ＲＮＡ水平表达。结果表明：８５％的病例ｃ－ｍｙｃＲＮＡ表达水平显著升高，粒、淋白血病细胞间无显著差异。粒系白血病中５９．４％ｐ５３基因的表达异常，ｃ－ｍｙｃ过高表达可作为预测疗效的指标。
Expression of p53 c myc gene in acute leukemia cells and its clinical implications were studied using DNA RNA Dot. The results show that: c myc expression of 85% cases was high and p53 expression of 59.5% cases in myeloid leukemia was low or deficiency in 40 cases of acute leukemia cells. The cases with high c myc expression had poor response to chemotherapy. These suggested: abnormal expression of p53 and c myc was present in acute leukemia cells, high c myc expression may be a predictor of resistance to chemotherapy.
出处
《白血病》
1997年第2期89-91,共3页
