24周运动后肥胖绝经妇女血清脂联素水平及胰岛素抵抗的变化

The Effect of 24-Week Exercise Program on Serum Adiponectin Level and the Insulin Resistance in Postmenopausal Obese Women

目的:探讨24周不同方式的规律运动对肥胖绝经妇女血清脂联素水平和胰岛素抵抗的影响。方法:将36名受试者随机分成有氧练习组(AE)、有氧练习结合抗阻力练习组(AE+RE)及对照组(CON),进行24周的实验,实验前后测量身体形态指标、空腹血糖(FPG)、血脂、胰岛素(FINS)及血清脂联素(ADI),并计算胰岛素抵抗指数(HOMA-IR)。结果:两运动组的体脂含量(FM)、体脂百分比(%F)、体重、腰臀比(WHR)、FPG、FINS和HOMA-IR水平均较实验前显著下降;血清ADI水平呈上升趋势(AE组上升7.7%,AE+RE组上升17.2%),但无统计学意义。实验后两运动组各指标间无显著性差异。按照实验后体重变化分组,体重下降大于3kg的组脂联素变化水平显著高于未下降组。结论:24周不同方式运动显著改善胰岛素抵抗状态,但对脂联素水平无显著影响;脂联素水平上升不是运动导致的胰岛素抵抗改善的必要条件。

Objective To study the influence of long term regular exercise on the serum adiponectin level, and the insulin resistance in postmenopausal obese women, aged 52.5±3.10 yrs with BMI of 27.65 ±1.45. Methods Thirty six subjects were randomly separated into three groups： aerobic exercise group （AE）, aerobic and resistance exercise group （AE＋RE） and control group （CON）. Experiment was lasted for 24 weeks. Body fat mass （FM）, body fat percentage （%F）, body weight （BW）, waist- to- hip ratio （WHR）, fasting blood glucose （FBG）, blood lipid, fasting insulin （FIN） and serum adiponectin （ADI） were measured before and after the experiment. Insulin resistance index （HOMA-IR） was calculated. Results After intervention, significantly reduction in FBG, FIN and HOMA-IR in two training groups was seen. Serum adiponectin presented an increasing trend in both training groups （increase of 7.7% in AE and 17.2% in AE＋RE）, however, there was no statistic significance. No significant differences in all parameters were observed between AE and AE＋RE. A significant negative correlation was observed between the change in adiponectin level and the change in %F, WHR and FBG. Adiponectin level in those with weight reduction equal or greater than 3kg was significantly higher than that in those with weight reduction equal or less than 0kg. Conclusion Exercise training could significantly reduce insulin resistance, whereas there was no significant effect on plasma adiponectin. Adiponectin was not responsible for the exercise-induced insulin resistance reduction.