98例肝胆疾病患者血清5′-核苷酸酶测定结果分析

Detection of 5′-Nucleotidase and Its Clinical Significance.

目的:探讨5′-核苷酸酶(5′-NT)在肝胆疾病诊断与鉴别诊断中的临床应用。方法:利用速率法测定35例健康人群和98例肝胆疾病病人血清5-′NT水平,并加以比较。结果:健康对照组,肝硬化组,肝癌组,胆囊炎和胆石症组,肝炎组,胆道梗塞性黄疸组血清5′-NT水平(-x±s)分别为:3.85±2.73U/L,9.10±3.98U/L,22.93±12.01U/L,18.51±7.56U/L,10.51±6.22U/L,36.07±19.28U/L,各肝胆疾病组的5′-NT值显著高于对照组(P<0.01),胆道梗塞性黄疸组高于其他各肝胆疾病组。结论:血清5-′NT活性有助于肝胆系统疾病的判断,尤其对肝胆系统梗阻性疾病的判断是一项重要的指标。

Objectives： To detect 5′-NT associated to hepatic diseases and to discuss the application of 5′-NT to diagnose and distinguish disease between hepatic and osteal. Methods： 35 cases in control team , total disease 98 cases , to measure their values of 5′- NT. Results： The average values of control , liver cirrhosis, liver cancer, cholelithiasis , hepatitis , infracted jaundice are respectively 3.85 ± 2.73U/L, 9.10 ± 3.98U/L, 22.93 ±12.01U/L, 18.51 ± 7.56U/L, 10.51 ± 6.22U/L, 36.07 ± 19.28U/L, the values in Liver ＆ gallbladder disease are prominently higher than those in control teams （ P 〈 0.01 ） . Conclusions： 5′-NT is a sensitive index to the diagnosis of liver disease. It can enhance the sensitivity and specificity of the diagnosis of liver disease.