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小檗碱对HeLa细胞黏附和移动作用的体外实验研究 被引量：4

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摘要 目的研究小檗碱体外对HeLa细胞黏附和移动的作用及机制。方法5、20、40mg/L小檗碱作用于HeLa细胞,黏附实验检测细胞黏附率,划痕损伤实验检测迁移率,流式细胞术测定MMP2、TIMP2的表达。结果HeLa细胞黏附率、迁移率明显降低,随药物浓度增大作用增强,小檗碱处理组MMP2阳性表达细胞减少,TIMP2阳性表达细胞增多,MMP2/TIMP2比值下降。结论小檗碱体外能抑制HeLa细胞黏附与转移,其机制可能与直接抑制细胞迁移运动及抑制细胞MMP2蛋白表达,促进TIMP2蛋白表达有关。
作者 来丽娜 赵娜 范毅敏
机构地区 长治医学院药理教研室 天津医科大学总医院外科研究所
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第1期13-14,共2页 Chinese Journal of Gerontology
关键词 小檗碱HeLa细胞 黏附 肿瘤转移
分类号 R285.5 [医药卫生—中药学] R329.25 [医药卫生—人体解剖和组织胚胎学]
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参考文献8

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二级参考文献9

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共引文献38

同被引文献66

  • 1智多,刘爽,钟璐.小檗碱通过调控长链非编码RNA肺腺癌转移相关转录因子1抑制卵巢癌的发生、发展[J].哈尔滨医科大学学报,2022,56(5):468-472. 被引量：1
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中国老年学杂志
2008年 第1期

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