摘要
HIV-1整合酶是由HIV病毒pol基因编码的分子量为32kDa的蛋白质,是HIV病毒复制的必需酶之一,它催化病毒DNA整合入宿主染色体DNA。人类细胞中没有HIV整合酶的类似物,理论上抑制整合酶对人体副作用很小。因此HIV-1整合酶成为继HIV-1蛋白酶,逆转录酶后治疗艾滋病的富有吸引力和合理的靶标。综述了HIV整合酶结构,抑制剂的研究以及以HIV-1整和酶为靶点治疗AIDS方法的最新研究进展。
HIV-1 integrase enzyme is a 32kDa protein encoded by HIV pol gene. It is responsible for integration of viral cDNA into host chromosomal DNA, which is indispensable for HIV replication. Since there was no functional equivalent for this enzyme in human ceils, inhibition of integrase will bring little side effect to human body. Thus HIV integrase has become an attractive and rational target for therapy of AIDS after reverse transcriptase and protease. The Recent research on HIV-1 integrase structure, inhibitors and new therapeutic method target at HIV integrase was reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2008年第1期80-86,共7页
China Biotechnology
基金
国家自然科学基金资助项目(30670424)
