子痫前期患者胎盘中人表皮生长因子受体1的表达研究

Placental expression of human epidermal growth factor receptor 1 in pre-eclampsia.

目的通过检测子痫前期患者胎盘滋养细胞人表皮生长因子受体1(ErbB1)的表达情况,探讨胎盘滋养细胞ErbB1表达与子痫前期的关系。方法采用RT-PCR法及免疫组织化学法检测20例正常妊娠妇女(正常妊娠组)与34例子痫前期患者(子痫前期组)胎盘ErbB1的表达。结果在子痫前期患者胎盘中,ErbB1表达明显高于正常妊娠组,两者相比差异有统计学意义(P<0.05)。结论胎盘中ErbB1表达的升高与子痫前期的发生密切相关。

Objective：To test the expression of human epidermal growth factor receptor1（ErbB1） in placenta and elucidate the relation-ship between it′s expression and the pathogenesis of pre-eclampsia.Methods：The placenta of normal pregnancies（20cases） and pregnancies accompanied by pre-eclampsia（34cases） were tested by reverse transcriptase polymerase chain reaction and Immunohistochemical assay.Results：The over-expression in placenta from pregnancies complicated with pre-eclampsia than normal pregnant placentas significantly（P〈0.05）.Conclusion：Over-expression of placental ErbB1 may play an important role in the pathogenesis of pre-eclampsia.