即时检验糖化血红蛋白在妊娠糖尿病筛查中的应用

The point of care test for saccharification hemoglobin in diagnosing pregnancy diabetes.

目的探讨糖化血红蛋白(HbA1c)即时检验(POCT)对筛查妊娠糖尿病(GDM)的应用价值。方法对68例正常妊娠组及32例GDM组进行了空腹血糖(FPG)、口服葡萄糖50g筛选测定(GCT)及即时检验HbA1c。结果GDM组FPG、GCT、HbA1c较正常妊娠组均显著增高(P<0.01)。HbAlc在GDM筛查中敏感性、特异性、准确性、阳性预测值、阴性预测值及Youden指数分别为81.3%、95.6%、91.0%、89.7%、91.5%、76.8%;HbA1c除敏感性和阴性预测值比GCT稍低外,其余指标均高于FPG、GCT。结论HbAlc POCT方法快速、简便、实用,取血量少,不易受其它因素影响。随时可测定,可作为GDM诊断筛查的指标。

Objective：To probe the value of the point of care test for saccharification hemoglobin in diagnosing pregnancy diabetes.Methods：To measure the fasting plasma glucose,oral glucose 50g screen,and POCT for HbAlc for contrasting 68 cases in normal gestation group and 32 cases in pregnancy diabetes group.Results：The results of FPG,GCT,HbAlc were significantly higher than those in normal gestation group obviously（P〈0.01）.Sensitivity,specificity,veracity,positive predictive value,negative predictive value and Youden index of HbAlc were 81.3%,95.6%,91.0%,89.7%,91.5%,76.8% respectively,which were higher than the FPG and GCT in addition to sensitivity and negative predictive value.Conculsion： The POCT for HbAlc is fast,simple,practical,the amount of blood fetched lacks,it is difficult to influence by other factors,can diagnose the index as GDM.