摘要
目的:制备盐酸伊立替康脂质体并考察提高脂质体稳定性的方法。方法:采用硫酸铵梯度法制备盐酸伊立替康脂质体。以粒径、外观、颜色、渗漏率作为指标,考察盐酸伊立替康脂质体的物理和化学稳定性。结果:硫酸铵梯度法制备的盐酸伊立替康脂质体呈圆球形,平均粒径为600nm,稳定性较好。结论:盐酸伊立替康脂质体不耐高温,将其制成冻干粉剂可显著提高药物稳定性。
Objective: To prepare Irinotecan liposomes and study its stability. Method: Ammonium sulfate gradient method was used to prepare Irinotecan liposomes, size of liposome, appearance, color, oxidation index were observed as indexes, Irinotecan liposome physical and chemical stability was inspected. Result: The average particle size of the liposomes were 600 nm in a pellet shape with a good stability. Conclusion : Irinotecan liposomes can not bear high temperature. Freeze-dried liposome can obviously improve its stability.
出处
《中国药师》
CAS
2008年第1期72-74,共3页
China Pharmacist