川赤芍的化学成分研究

Chemical constituents of Paeonia veitchii

目的研究川赤芍Paeonia veitchii的化学成分。方法利用硅胶柱色谱进行分离纯化，通过理化性质和波谱数据分析鉴定化合物结构。结果分离得到9个化合物，分别鉴定为芍药苷（paeoniflorin，Ⅰ）、羟基芍药苷（hydroxypaeoniflorin，Ⅱ）、苯甲酰芍药苷（benzoylpaeoniflorin，Ⅲ）、苯甲酰羟基芍药苷（benzoylhydroxypaeoniflorin，Ⅳ）、芍药苷内酯（albifiorin，Ⅴ）、paeonisothujone（Ⅵ）、牡丹皮酸A（mudanpinoic acid A，Ⅶ）、邻羟基苄醇（2-hydroxybenzyl alcohol，Ⅶ）、双（2-羟苄基）醚[-6／s（2-hydroxybenzyl）ether，Ⅸ]。结论化合物Ⅸ为首次从天然产物中获得，化合物Ⅳ、Ⅵ～Ⅸ为首次从该植物中分离得到。

Objective To study the chemical constituents of Paeonia veitchii. Methods Isolation and purification were carried out on repeated silica gel column chromatography. The structures of the compounds were identified by physico-chemical properties and spectral analyses. Results Nine compounds were isolated and identified as paeoniflorin （ Ⅰ ）, hydroxypaeoniflorin （ Ⅱ ）, benzoylpaeoniflorin （ Ⅲ ）, benzoylhydroxypaeoniflorin （ Ⅳ ）, albiflorin （ Ⅴ ）, paeonisothujone （ Ⅵ ）, mudanpinoic acid A （Ⅶ）, 2-hydroxybenzyl alcohol （Ⅷ）, bis （2-hydroxybenzyl） ether （ Ⅸ ）. Conclusion Compound Ⅸ is obtained from natural products for the first time. Compounds Ⅳ, Ⅵ -- Ⅸ are isolated from this plant for the first time.