原发性高血压患者血浆一氧化氮、内皮素变化

Plasma Nitric Oxide and Endothelin in Patients with Essential Hypertension

目的探讨原发性高血压患者血浆一氧化氮和其对应缩血管性物质内皮素含量变化及其临床意义。方法６０例原发性高血压患者，平均年龄５４．５±９．２岁，男性３１例，女性２９例，接受血浆比色法的硝酸根和放免法内皮素含量测定。结果患者血浆硝酸根含量明显低于正常人，而内皮素含量却明显高于正常人。这种变化和疾病严重程度相平行，而和病程无关。结论血管内皮细胞产生的这一对扩张和收缩血管的因子的失衡在高血压的发病上起重要作用。

Aim To survey the changes of plasma nitric oxide (NO) and endothelin (ET) in hypertension.\ Methods\ Sixty hypertensive patients,average age 54 5 years,male 31 cases and female 29 cases,were examined the plasma nitrite by colorimeteric method and the plasma endothelin by RIA method.\ Results\ The nitrite level was reduced and the ET was increased markdly in hypertensive patients, the change was correlated to the severity of disease.\ However,there seems no significant difference between the different duration of hypertension .\ Conclusion\ The unbalancy of the two factors released by the vascular endothelial cell may be the important causes of the hypertension.