荧光偏振免疫法测定环孢素A全血浓度结果分析

Analysis of trough concentration of CsA in whole blood by FPIA

采用荧光偏振免疫法（ＦＰＩＡ）测定肾移植受者环孢素Ａ（ＣｓＡ）全血谷浓度，结果发现食物、性别、肝脏功能等均是影响ＣｓＡ全血谷浓度的重要因素；从免疫抑制效果看，术后３个月、３～６个月、６个月以上的理想稳态血浓范围分别为２００～３８０ｎｇ·ｍｌ－１、１５０～３３０ｎｇ·ｍｌ－１和１００～２５０ｎｇ·ｍｌ－１。

Cyclosporine A has greatly improved graft survival in kidney transplants.The trough concentration of CsA in whole blood was determined by FPIA.The results showed that food,sex,liver function were important factors influencing the trough concentration.It was found that under 3 months 3￣6months and more than 6 months after operation,the expected steady state range of blood concentration was 200￣380ng\5ml -1 ,150￣330ng\5ml -1 and 100￣250ng\5ml -1 respectively.