PGI_2、TXA_2和肾髓质PGE_2与高蛋白负荷时肾小球滤过率增高的关系

The role of PGF 2、PGI 2、TXA 2 in the Mechanism of Protein Loading on Glomerular Filtration Rate

用放射免疫分析法测定了蛋白质食入量为（２．０９～２．７９）ｇ／１００ｇＢＷ（２４ｈ）的１５只大鼠（实验组）和正常蛋白质食入量的１０只大鼠（对照组）的腹主动脉血、肾静脉血、尿６－ｋｅｔｏ－ＰＧＦ１α的浓度、ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１ａ比值以及肾髓质中的ＰＧＥ２浓度。实验组大鼠肾髓质中ＰＧＥ２浓度及尿中６－ｋｅｔａ－ＰＧＦ１ａ浓度明显高于对照组（Ｐ＜０．００１），实验组大鼠腹主动脉血、肾静脉血、尿中ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比值明显低于对照组（Ｐ＜０．０１和Ｐ＜０．０００１）。以上结果提示高蛋白摄入时肾脏合成、释放的ＰＧＥ２增多以及ＴＸＡ２减少，ＰＧＩ２增多在肾小球滤过率增加的机制中具有重要作用。

The concentration of the thromboxane B 2 (TXB 2) and 6 keto PGF 1α (PGF 1α ) in abdominal aorta、renal vein and urine, the stable metabolic products of thromboxane A 2 (TXA 2) and prostaglandin I 2 (PGI 2), and prostaglandin E 2 (PGE 2) in medulla of kidney were measured by radioimmunoassy respectively in 15 wistar rats with high protein diet (2 09 2 79 g/100 g body weight/day) (experimental group) and 10 wistar rats with normal protein diet (control group) The level of PGE 2 in medulla of kidney and PGE 1α in urine were increased significantly (P<0 0001) and the level of TXB 2 in abdominal arota、renal vein and urine were decreased significantly (P<0 01 and P<0 0001) in experimental group and TXB 2/6 keto PGF 1α ratios in experimental group were decreased significantly (P<0 01).Our results suggest that the increase of PGE 2 by the medulla of kidney and the increase of PGI 2 and the decrease of TXA 2 take important role in the mechanism of protein loading on glomerular filtrition rate