四种骨组织替代材料对成骨细胞IGF-ImRNA表达水平影响的研究

The Research on Effect of Four Kinds of Substitutive Materials for the Bone Tissues on IGF I mRNA Expression Level of Osteoblast

采用ＳＤ乳鼠颅顶骨体外培养成骨细胞，运用核酸分子原位杂交技术研究了三个时期、４种骨组织替代材料对成骨细胞ＩＧＦ－ＩｍＲＮＡ表达水平的影响。结果表明，替代材料能够影响成骨细胞ＩＧＦ－ＩｍＲＮＡ的表达，其表达规律的检测有可能成为评价骨组织替代材料生物相容性的一个指标。

The authors studied the expression level of IGF I mRNA of osteoblasts cultured from the rats' calvarias, affected by four kinds of substitutive materials for bone tissues, using the technique in situ hybridization. The result showed that the substitutive materials could affect the expression level of IGF I mRNA of osteoblasts. The measurement of expression regulation may be a parameter for evaluation of biocompatibility of substitutive materials for bone tissues.