颊粘膜鳞癌微血管密度与增殖细胞比率的定量研究

A quantitative study of microvascular density and proliferating cell ratio in buccal mucosa squamous cell carcinoma

用ＡＢＣ酶标法定量分析了颊癌内微血管密度和增殖细胞比率，其与正常组织的差别及参考价值。颊癌内这二个指标均明显高于正常颊部组织，分别为后者的２０８％（Ｐ＜０．０５）和３３５％（Ｐ＜０．０５）。研究结果表明，微血管密度改变和增殖细胞比例变化均反映了肿瘤组织的恶性特征。增殖细胞分布区域与颊癌内微血管密集增生区域相一致，主要分布在肿瘤周边部和癌巢的基底部；二者间存在密切的依存关系，呈直线正相关。经统计学处理，其直线回归方程为Ｙ＝２０．０８０１＋１．３０４４Ｘ（ｒ＝０．９６８０，Ｐ＜０．０１）。本研究证明颊癌内血管生成与癌细胞增殖相互促进，是颊癌生物学行为表达的二个重要指标，对判断颊癌的发展和疗效评价有重要意义。

By the ABC enzyme labelling method we studied the microvascular density and proliferating cell ratio in buccal mucosa squamous cell carcimoma (BMSCC) and in normal buccal tissues quantitatively. These two parameters in BMSCC are 208% and 335% ( P <0.05) respectively which are distinctly higher than those of the normal buccal tissues, indicating malignant features of the carcinoma. The distribution of proliferating cells, corresponds to the area where the microvascular density is high, mainly in the periphery and basal parts of cancer nests. There is a dependent relationship between them, showing a linear positive correlation statistically. The results confirm that angiogenesis and cancer cell proliferation promote each other. They are two important indexes of the local biological behavior of BMSCC and are very important to predict the malignant potential and to evaluate therapeutic effect for BMSCC