摘要
为探讨转化生长因子β1在口腔粘膜下纤维性变发病机理中的作用,作者应用原位杂交方法,对25例口腔粘膜下纤维性变(oralsubmucousfibrosis,OSF)、5例正常口腔粘膜(NOR)及10例口腔扁平苔藓(orallichenplanus,OLP)组织角朊细胞中转化生长因子β1(transforminggrowthfactorβ1,TGFβ1)mRNA进行了检测。结果:15例(60%)OSF组织角朊细胞中有TGFβ1mRNA表达,阳性表达主要分布于早、中期OSF组织角朊细胞中;5例NOR及10例OLP组织角朊细胞表达呈阴性。结果提示:OSF组织角朊细胞可合成分泌TGFβ1,TGFβ1在OSF的发病机理中可能起重要作用,可能作为一中间介质参与了OSF的发病过程。
To explore significance of transforming growth factor β 1 (TGF β 1) in the pathogenesis of oral submucous fibrosis (OSF), TGF β 1 mRNAs in keratinocytes of the paraffin embeded tissues of 25 OSF cases, 5 normals (NOR) and 10 oral lichen planus (OLP) were determined by the in situ hybridization technique. The result showed that there was an expression of TGF β 1 mRNA in keratinocytes of 15 OSFs (60%). The positive expression of TGF β 1 mRNA was mainly in kerationcytes of early and middle stage OSF. There was no expression in that of 5 NORs and 10 OLPs. The study suggests that keratinocyte of OSF tissue may synthesize and release TGF β 1 which may play an important role in the pathogenesis of OSF and participate as a mediator in the pathogenetic process of OSF.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1997年第4期239-241,共3页
Chinese Journal of Stomatology
关键词
口腔粘膜下
纤维性变
角朊细胞
TGFΒ1
OSF
Oral submucous fibrosis Keratinocyte Transforming growth factor β 1 In situ hybridization