L-OHP联合卡培他滨治疗晚期大肠癌的临床观察

Clinical observation of therapeutic effect of L-OHP and Capecitabine on terminal advanced colorected carcinoma

目的观察奥沙利铂（L-OHP）联合卡培他滨治疗晚期大肠癌的疗效和毒副反应。方法选用晚期或术后有残留癌灶或复发转移有可测癌灶的大肠癌患者46例。静脉滴注奥沙利铂130mg/m^2,第1天。卡培他滨2500mg/m^2,分早晚2次口服,第1～14天,每3周为1周期。结果46例患者中CR2例,PR20例,SD11例,PD13例,近期有效率（CR＋PR）为47.7%。中位生存期（MST）12.8个月,中位疾病进展时间（TTP）7.9个月。毒副反应主要为手足综合征,神经毒性多为Ⅰ～Ⅱ度。结论奥沙利铂联合卡培他滨的方案疗效高,毒副反应小,患者易耐受,生活质量高。

Objective To evaluate tha effects of L-OHP and Capecitabine on terminal advanced colorected carcinoma.Methods 46 patients of terminal advanced colorected carcinoma or having minor portion pf tumors or occurring recurrence after operation were treated with L-OHP and Capecitabine,L-OHP（130 mg/m^2）was performed in the first day and Capecitabine（2500 mg/m^2,Twice per day）was performed oral administration for 14 days for 3 weeks（one couse of treatment）. Results CR,PR,SD and PD took place in 2 cases,20 cases,11cases and 13cases respectively.And the recte of validity in tha near future（CR＋PR）was 44.7%.MST was 12.8 monthes and TTP was 7.9 months.The primary side and toxit effect was hand feat syndrome,and the degree of nerve was about Ⅰ to Ⅱ.Conclusion The L-OHP and apecitabine on terminal advanced colorected carcinomal has advantages including good effects,less side effects,more recipiented and hogh quality lives.