磁共振静脉成像诊断静脉窦栓塞的实验研究

Magnetic resonance venography in cerebral venous sinus occlusion: experimental study

目的探讨磁共振静脉成像对静脉窦栓塞的诊断价值,并以DSA检查结果和解剖标本为标准,评价其有效性。方法采用经静脉插管的介入方法将弹簧圈和/或明胶海绵放置在猪脑静脉窦的不同位置制作静脉窦完全或不完全栓塞的动物模型。对所有模型进行磁共振静脉成像和DSA检查,比较两种检查方法对静脉窦栓塞的显示能力。2周后处死动物,开颅取脑,观察大体标本的形态和色泽,剥开硬脑膜观察弹簧圈等栓塞材料在硬脑膜内的准确位置。结果磁共振静脉成像成功的显示上矢状窦中后1/3Rolandic静脉前矢状窦栓塞1例,Rolandic静脉处栓塞3例,Rolandic静脉后1～2cm处栓塞2例,直窦栓塞1例,窦汇和直窦栓塞1例。结论磁共振静脉成像方法可以清晰的显示脑静脉窦栓塞的情况并对其作出正确的诊断。

Objective To discuss the value of magnetic resonance venography （MRV） in cerebral venous sinus occlusion and compare the features of MRV with DSA. Methods Make venous sinus occlusion animal model by directly puncturing deep femoral vein with Seldinger technique, the vein catheter was placed into different part of superior sagittal sinus and straight sinus, sinus confluens, which were emphraxised with platinum spring coil and/or gelatin sponge. All animal were performed MRV and DSA. Two weeks later, put the pig to death and observe the form and color luster alteration of cerebral corpus, then dissect the cerebral corpus. Results MRV display that the anterior part of Rolandic vein （n=1）, Rolandic vein （n=2）, the posterior part of Rolandic vein （n=3）, straight sinus （n=1）, straight sinus combining sinus confluens （n=1）, and right sigmoid sinus （n=1） were occluded. Conclusion MRV can exactly evaluate venous sinus occlusion quickly and noninvasive.